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STABILIN-1-INTERACTING CHITINASE-LIKE PROTEIN, (SI-CLP)

STABILIN-1-INTERACTING CHITINASE-LIKE PROTEIN, (SI-CLP)

Cat no: S7950-56A

Supplier: United States Biological
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SI-CLP is a secretory protein which is up-regulated in response to interleukin-4 and dexamethasone in activated macrophages. SI-CLP is also expressed by T- and B-lymphocytes, and by cells of monocytic and epithelial origin. SI-CLP is the ligand for stabilin-1, an intracellular sorting receptor which sorts SI-CLP into late endosomes and secretory lysosomes in activated macrophages. Applications: Suitable for use in Flow Cytometry and Western Blot. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:10-1:100 Use 10ul of the suggested working dilution to label 1x10e6 cells in 100ul. Membrane permeabilization is required for this application. Western Blot: Detects bands of approximately 33 and 39kD in U937 cell lysates. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: S7950-56A
Reactivities: Human
Hosts: Rat
Applications: Flow Cytometry, Western Blot
Size: 200ug
Form: Supplied as a liquid in PBS, pH7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein G affinity chromatography.
References: 1. Kzhyshkowska, J. et al. (2006) Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway. Blood. 107: 3221-3228. 2. Kzhyshkowska, J. et al. (2006) Stabilin-1, a homeostatic scavenger receptor with multiple functions. J. Cell. Mol. Med. 10: 635-649.
Additional info: Detects human Stabilin-interacting chitinase like protein (SI-CLP), a novel member of the Glyco-18- domain containing protein family.

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