Home  >  Products  >  SPZ1 (Spermatogenic Leucine Zipper Protein 1, FLJ25709, Testis-specific Protein 1, Testis-specific Protein NYD-TSP1, TSP1)

SPZ1 (Spermatogenic Leucine Zipper Protein 1, FLJ25709, Testis-specific Protein 1, Testis-specific Protein NYD-TSP1, TSP1)

Cat no: S6010-10

Supplier: United States Biological
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Spermatogenic leucine zipper protein 1 is a member of the basic helix-loop-helix (bHLH) family of transcription factors which is expressed specifically in the testis and epididymis. Studies show that SPZ1 acts downstream of mitogen-activated protein kinase (MAPK), an extracellular signal-regulated kinase 1:2 to up-regulate cell proliferation and tumorigenesis. Also, through an interaction with proliferating cell nuclear antigen (PCNA) promoter, SPZ1 induced cell proliferation concomitant with an increase in PCNA gene expression. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1-3ug/ml Immunohistochemistry (formalin fixed paraffin embedded): 5ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Testis Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S6010-10
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Hrabchak, C. et al. J. Biol. Chem. 279:37079-37086 (2004). 2. Atchley, W.R. et al. Proc. Natl. Acad. Sci. 94:5172-5176 (1997). 3. Hsu, S.-H. et al. Cancer Res. 65:4041-4050 (2005).
Additional info: Recognizes human SPZ1. Species Crossreactivity: chimpanzee, mouse, rat. Species sequence homology: canine, rhesus monkey.

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