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SPIR1 (Protein Spire Homolog 1, Spir-1, SPIRE1, KIAA1135)

Cat no: S5532-20

Supplier: United States Biological
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SPIR1 belongs to the family of Wiskott-Aldrich homology region 2 (WH2) proteins involved in actin organization. The C-terminal region of SPIR1 encodes a zinc finger structure highly homologous to FYVE motifs. The protein also possesses a region highly homologous with other Spir family proteins located adjacent (N-terminal) to the modified FYVE domain and is designated as Spir-box. The protein colocalized specifically with Rab11 GTPase, which is localized at the trans-Golgi network (TGN), post-Golgi vesicles, and the recycling endosome. SPIR1 actin organizer is targeted to intracellular membrane structures by its modified FYVE zinc finger and is involved in vesicle transport processes, providing a novel link between actin organization and intracellular transport. The human SPIR1 gene is localized in the chromosomal region 18p11.21. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S5532-20
Reactivities: Human
Hosts: Rabbit
Applications: ELISA
Size: 100ul
Form: Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Serum
References: 1. Kerkhoff, E. et al. Curr. Biol. 11:1963-1968 (2001).
Additional info: Recognizes human SPIR1.

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