Home  >  Products  >  Sphingolipid Receptor (Edg8/S1P5, Endothelial Differentiation G-protein-coupled Receptor 8, EDG8, Edg-8, Sphingosine 1-phosphate Receptor 5, S1P Receptor 5, S1P5, Sphingosine 1-phosphate Receptor Edg-8, S1P Receptor Edg-8, S1PR5, SPPR-1, SPPR-2)
Sphingolipid Receptor (Edg8/S1P5, Endothelial Differentiation G-protein-coupled Receptor 8, EDG8, Edg-8, Sphingosine 1-phosphate Receptor 5, S1P Receptor 5, S1P5, Sphingosine 1-phosphate Receptor Edg-8, S1P Receptor Edg-8, S1PR5, SPPR-1, SPPR-2)

Sphingolipid Receptor (Edg8/S1P5, Endothelial Differentiation G-protein-coupled Receptor 8, EDG8, Edg-8, Sphingosine 1-phosphate Receptor 5, S1P Receptor 5, S1P5, Sphingosine 1-phosphate Receptor Edg-8, S1P Receptor Edg-8, S1PR5, SPPR-1, SPPR-2)

Cat no: S5451-08C

Supplier: United States Biological
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Sphingosine 1-phosphate receptor Edg8 is a multi-pass membrane protein belonging to the G-protein coupled receptor 1 family and coupled to both the G (i:0) alpha and G (12) subclass of heteromeric G-proteins. Edg8 acts as a receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) as well as for lysolipid mediator lysophosphatidic acid (LPA) and gives diverse physiological effect on most types of cells and tissues. Edg8 may also play a regulatory role in the transformation of radial glial cells into astrocytes and affect proliferative activity of these cells. It is widely expressed in white matter tracts of brain, spleen, peripheral blood leukocytes, placenta, lung, aorta, and fetal spleen. Over expression of Edg8 leads to a lymphoproliferative disorder often associated with the autoimmune disease known as leukemic large granular lymphocyte (LGL). Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1-3ug/ml Immunohistochemistry (paraffin): 5-10ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human, mouse and rat brain lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S5451-08C
Reactivities: Human, Mouse, Rat, Canine, Non-Human Primate
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: 1. Im, DS. et al. J. Biol. Chem. 275:14281-14286 (2000).
Additional info: Recognizes human Sphingolipid Receptor Edg8/S1P5. Species Crossreactivity: canine, mouse, monkey, rat. Species sequence homology: opossum, bovine.

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