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Sphingolipid Receptor (Edg1/S1P1)

Cat no: S5451-01A

Supplier: United States Biological
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EDG1, a Lysophospholipid/Lysosphingolipid Receptor, binds sphingosine-1-phosphate and may control cell proliferation, survival, and suppression of apoptosis. Overexpression of EDG-1 leads to increased cell-cell aggregation and overexpression of cadherins. EDG-1 transcripts have been reported to be present in embryonic and adult brain, lung alveolar macrophages, vascular smooth muscle cells, endothelial cells, fibroblasts, melanocytes, and TAg-Jurkat T cells, but to be absent from breast cancer cell lines. ESTs have been isolated from brain, breast, heart, heart/melanocyte/uterus, kidney, liver, liver/spleen, lung, nerve, placenta, prostate, tonsil, uterus, and vessel libraries. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry(Formalin-fixed Paraffin): 10ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: S5451-01A
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Immunohistochemistry
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.7, 0.09% sodium azide.
P type: Pab
Purity: Purified by Protein G affinity chromatography.
Alternative names: CHEDG1, D1S3362, ECGF1, EDG-1, S1PR1
Additional info: Recognizes human Sphingolipid Receptor Edg1/S1P1 (aa25-40). Species Sequence Homology: mouse, rat: 89/100.

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