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SOX17 (Transcription Factor SOX-17)

Cat no: S5364-45C

Supplier: United States Biological
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SOX17, also known as Transcription factor SOX-17, is, as the name suggests, a transcription factor and a probable transcriptional activator in the premeiotic germ cells. It belongs to the SRY-related HMG box family of transcription factors with a high-mobility group DNA-binding domain (HMG box) that plays a key role in embryogenesis and binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. SOX17 plays an essential role in cardiac mesoderm specification as well as in definitive hematopoiesis, maintaining fetal hematopoietic stem cells, hematopoiesis in the fetal liver and yolk sac. Along with beta-catenin it is known to cooperate in the regulation of transcription of endodermal genes. Defects in SOX17 are known to cause a severe defect in fetal hematopoiesis. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-3ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Mouse embryo brain lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S5364-45C
Reactivities: Human, Mouse, Chicken/Bird, Porcine
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein A affinity chromatography.
References: 1. Kanai, Y. et al. J. Cell Biol. 133: 667-681 (1996). 2. Liu, Y. et al. Proc. Nat. Acad. Sci. 104: 3859-3864 (2007). 3. Sinner, D. et al. Development 131: 3069-3080 (2004).
Additional info: Recognizes human SOX17. Species Crossreactivity: chicken, chimpanzee, mouse, opossum, porcine, rhesus monkey. Species sequence homology: rat.

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