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SOX1 (Transcription Factor SOX-1)

Cat no: S5364-02C

Supplier: United States Biological
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SOX1, also known as SRY (sex determining region Y)-box 1, is a transcription factor belonging to the SRY-related HMG box family of transcription factors with a HMG box DNA-binding domain. SOX1 works through multiple independent pathways to promote neuronal cell fate determination and differentiation. This nuclear protein acts as a modulator of LINE retroposons promoter activity and is also involved in the development of the central nervous system, mainly neural and lens development. Transcriptional activator SOX1 binds directly to the HES1 promoter and suppresses HES1 transcription, thus attenuating Notch signaling. It also binds to beta-catenin and suppresses beta-catenin-mediated TCF/LEF signaling, thus potentially attenuating the WNT signaling pathway. Expression of SOX1 is seen mostly in embryonic tissues and moderately in brain. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1-4ug/ml Immunohistochemistry (formalin fixed paraffin embedded): 5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S5364-02C
Reactivities: Human, Mouse, Non-Human Primate, Xenopus/Amphibian
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Collignon, J. et al. Development. 122:509-520 (1996). 2. Malas, S. et al. Mammalian Genome. 8:866-868 (1997). 3. Bylund, M. et al. Nature Neurosci. 6:1162-1168 (2003).
Additional info: Recognizes human SOX1. Species Crossreactivity: chimpanzee, equine, New World monkey, mouse, opossum, xenopus.

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