Home  >  Products  >  SORL1, CT (Sortilin-related Receptor, Low-density Lipoprotein Receptor Relative with 11 Ligand-binding Repeats, LDLR Relative with 11 Ligand-binding Repeats, LR11, SorLA-1, Sorting Protein-related Receptor Containing LDLR class A Repeats, C11orf32)
SORL1, CT (Sortilin-related Receptor, Low-density Lipoprotein Receptor Relative with 11 Ligand-binding Repeats, LDLR Relative with 11 Ligand-binding Repeats, LR11, SorLA-1, Sorting Protein-related Receptor Containing LDLR class A Repeats, C11orf32)

SORL1, CT (Sortilin-related Receptor, Low-density Lipoprotein Receptor Relative with 11 Ligand-binding Repeats, LDLR Relative with 11 Ligand-binding Repeats, LR11, SorLA-1, Sorting Protein-related Receptor Containing LDLR class A Repeats, C11orf32)

Cat no: S5353-02L

Supplier: United States Biological
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SORL1 is likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. It binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. SORL1 binds the receptor-associated protein (RAP). It could play a role in cell-cell interaction. SORL1 is expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole; low expression in the putamen and the thalamus. It is also found in spinal cord, testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart. Moreover, it is expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone marrow and adrenals. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.3-1ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Mouse Brain lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S5353-02L
Reactivities: Mouse
Hosts: Goat
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Jacobsen L, Madsen P, Jacobsen C, Nielsen MS, Gliemann J, Petersen CM.Activation and functional characterization of the mosaic receptor SorLA/LR11.J Biol Chem. 2001 Jun 22;276(25):22788-96. Epub 2001 Apr 9. PMID: 11294867.
Additional info: Recognizes mouse SORL1. Species sequence homology: canine, human, rat.

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