Home  >  Products  >  Somatostatin Receptor Type 5 (Somatostatin Receptor 5, Somatostatin Receptor Subtype 5, SS5R, SS5-R, SS-5-R, SSTR5)

Somatostatin Receptor Type 5 (Somatostatin Receptor 5, Somatostatin Receptor Subtype 5, SS5R, SS5-R, SS-5-R, SSTR5)

Cat no: S5331-56E

Supplier: United States Biological
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Somatostatin is a multifunctional protein affecting exocrine and endocrine protein secretion, neurotransmission, and neuronal modulation and regulating cell proliferation. All these functions of Somatostatin are executed through a class of GPCR protein family members called somatostatin receptor. TillDte, 6 classes of somatostatin receptors have been discovered out of which SSTR5, 364aa protein, is a receptor subtype expressed predominantly in the pituitary and hypothalamus region of brain. Studies revealed that SSTR5 contains seven transmembrane regions and undergoes homodimerization and also heterodimerizes with SSTR1. Although the specific functions of SSTR5 are still elusive, the studies indicate that it complements SSTR2 regulation of ACTH secretion. Polymorphisms in SSTR5 gene have been observed in patients with acromegaly. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.1-1ug/ml Immunohistochemistry (paraffin): 10ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human pancreas cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S5331-56E
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Ben-Shlomo et.al JBC 280 (25) 24011-24021 (June 24, 2005)
Additional info: Recognizes human SSTR5. Species sequence homology: chimpanzee.

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