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Somatostatin Receptor 1 (Somatostatin Receptor Isoform 1, Somatostatin Receptor Type 1, Somatostatin R1, SSTR1, SSTR-1, SRIF-2)

Cat no: S5331-40C

Supplier: United States Biological
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The Somatostatin family of receptors have five members, sst1-sst5, as well as two isoforms of Somatostatin receptor 2, sst2A and sst2B. They are coupled to G protein and are involved in regulation of numerous processes including secretion of insulin, glucagons and growth hormone and excitation of neurons in central and peripheral nervous system. Applications: Suitable for use in Immunohistochemistry (Fr) (paraffin-embedded sections). Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Positive Control: Pancreas Cellular Localization: Cytoplasmic Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: S5331-40C
Reactivities: Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 500ul
Form: Supplied as a liquid in PBS, pH 7.2.
P type: Pab
Isotype: IgG
Purity: Serum
References: Florio T et al. Somatostatin receptor 1 (SSTR1)-mediated inhibition of cell proliferation correlates with the activation of the MAP kinase cascade: role of the phosphotyrosine phosphatase SHP-2. J Physiol Paris 94:239-50 (2000). Schulz S et al. Localization of five somatostatin receptors in the rat central nervous system using subtype-specific antibodies. J Physiol Paris 94:259-64 (2000). Gu YZ et al. Development and use of a receptor antibody to characterize the interaction between somatostatin receptor subtype 1 and G proteins. Mol Pharmacol 48:1004-14 (1995).
Additional info: This antibody reacts with a 60kD protein, known as Somatostatin. Receptor. Species Crossreactivity: Crossreacts with Rat and Mouse.

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