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Somatostatin (Growth Hormone Release-Inhibiting Factor, SST)

Cat no: S5331-12A

Supplier: United States Biological
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Somatostatin was originally isolated from the hypothalamus and characterized by its ability to inhibit release of growth hormone from the pituitary gland. It exists in two forms, somatostatin-14, composed of 14 amino acids and somatostatin-28, a prohormone composed of 28 residues. The Somatostatin antibody will label D cells of the endocrine mammalian pancreas and also cells of the hypothalamic parvicellular region. It may prove useful for the identification of tumors and hyperplasias of the pancreatic islets. Applications: Suitable for use in Immunofluorescence and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Immunohistochemistry (Paraffin): 1:1000-1:4000 Immunofluorescence: 1:20-1:40 Optimal dilutions to be determined by the researcher. Positive Control for Immunohistochemistry: Pancreas Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S5331-12A
Reactivities: Human, Rat, Canine, Feline, Porcine, Sheep
Hosts: Rabbit
Applications: Immunofluorescence, Immunohistochemistry
Size: 50ul
Form: Supplied as a liquid, 0.09% sodium azide.
P type: Pab
Isotype: IgG
Purity: Serum
References: 1. Anderson, R.M. et al. (2009) Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regeneration. Dev Biol. 334: 213-23. 2. Nowicki, M. et al. (2007) Peptidergic and nitrergic innervation of the pineal gland in the domestic pig: an immunohistochemical study. Anat Histol Embryol. 36: 311-20.
Additional info: Recognizes somatostatin expressing cells in the pancreas and parvicellular structures in the basal hypothalamus of humans. Species Crossreactivity: feline, rat, sheep, canine, porcine and zebrafish

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