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Solute Carrier Family 4 (SLC4A11, Sodium Borate Transporter, Member 11

Cat no: S5329-04

Supplier: United States Biological
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This gene encodes a voltage-regulated, electrogenic sodium-coupled borate cotransporter that is essential for borate homeostasis, cell growth and cell proliferation. Mutations in this gene have been associated with a number of endothelial corneal dystrophies including recessive corneal endothelial dystrophy 2, corneal dystrophy and perceptive deafness, and Fuchs endothelial corneal dystrophy. Multiple transcript variants encoding different isoforms have been described. Applications: Suitable for use in ELISA and Western Blot. Other applications have not been tested. Recommended Dilutions: Peptide ELISA Titer: 1:32,000 Western Blot: 0.3-1ug/ml ~90kD band observed in Human, Mouse and Rat Kidney lysates (calculated MW of 99.6kD according to NP_114423.1). Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S5329-04
Reactivities: Human, Mouse, Rat
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by peptide affinity chromatography.
Alternative names: solute carrier family 4, sodium bicarbonate transporter-like, member 11, solute carrier family 4 member 11, sodium-coupled borate cotransporter 1, bicarbonate transporter related protein 1, OTTHUMP00000030097, dJ794I6.2, NABC1, MGC126419, MGC126418, CHED2, CDPD1, CDPD, BTR1, solute carrier family 4, sodium borate transporter, member 11, SLC4A11
References: 1. Hemadevi B, Veitia RA, Srinivasan M, Arunkumar J, Prajna NV, Lesaffre C, Sundaresan P. Identification of mutations in the SLC4A11 gene in patients with recessive congenital hereditary endothelial dystrophy.Archives of ophthalmology 2008 May 126 (5): 700-8.
Additional info: Recognizes human SLC4A11. Species crossreactivity: mouse, rat. Species sequence homology: canine, bovine.

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