Home  >  Products  >  SODD (Silencer of Death Domains, BAG Family Molecular Chaperone Regulator 4, BCL2-associated Athanogene 4, BAG4, BAG-4, DKFZp586O2022)

SODD (Silencer of Death Domains, BAG Family Molecular Chaperone Regulator 4, BCL2-associated Athanogene 4, BAG4, BAG-4, DKFZp586O2022)

Cat no: S2000-03A

Supplier: United States Biological
0 reviews | Write a Review Pencil
Several cell surface receptors that are involved in apoptosis contain intracellular death domains and are capable of triggering apoptosis when activated by their respective ligands (1). Due to presence of these death domains and presence of various stimuli in the serum as well as overexpression leading to receptor oligomerization, which leads to constitutive activation of the apoptotic pathway, it has been extremely difficult to generate permanent cell lines overexpressing specific receptors in culture. However, in normal states, this death domain activity is silenced presumably due to presence of other cellular factors. SODD (Silencer of Death Domain), a DR3 associated protein, was isolated by yeast two-hybrid interaction assays (2). SODD associates with the intracellular domains of TNF-R1, but not with those of TNF-R2, Fas, DR4, or DR5. Overexpression has been found to suppress the TNF induced cell death as well as NF-kB activation (2). SODD may act as a negative regulatory protein that is normally associated with death domain of TNF-R1 and probably inhibit self-oligomerization properties of death domain and maintain TNF-R1 in an inactive, monomeric state. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: HeLa cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S2000-03A
Reactivities: Human, Mouse, Rat, Bovine, Canine, Non-Human Primate
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: 1. Ashkenazi, A. and Dixit, VM. Science 281: 1305, (1998). 2. Jiang,Y., Woronicz, JD, Liu, D., and Goeddel, DV. Science 283: 543-546 (1999).
Additional info: Recognizes human SODD. Species Crossreactivity: canine, bovine, mouse, rat, rhesus monkey.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*

Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave