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SNRPA1 (U2 Small Nuclear Ribonucleoprotein A', U2 snRNP-A')

Cat no: S1014-96H3

Supplier: United States Biological
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SNRPA1, a 28kD protein, is a specific component of U2 snRNP particle and consists of a unique N-terminal leucine-rich region and an extremely hydrophobic RNA-binding C-terminal region. It lacks segments homologous to RNP1 and RNP2, common aa motifs found in several RNA-binding proteins. It associates with U2 snRNP and participates in transcription and pre-mRNA splicing. It might play an important role in cell division and proliferation. Patients with connective tissue disorders often produce autoantibodies against snRNP particles. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 0.1-1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S1014-96H3
Reactivities: Human
Hosts: Rabbit
Applications: ELISA
Size: 100ug
Form: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: 1. Fong,Y.W. and Zhou,Q. Stimulatory effect of splicing factors on transcriptional elongation Nature 414 (6866), 929-933 (2001). 2. Sillekens et.al Nucleic Acids Res., 17(5):1893-906 (1989 Mar 11).
Additional info: Recognizes human SNRPA1. Species sequence homology: mouse, rat, chimpanzee, bovine, chicken.

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