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Smoothened (Smoothened Homolog, SMO, SMOH, Gx, HGNC:11119, Protein Gx)

Cat no: S1014-63E

Supplier: United States Biological
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Smoothened drosophila homolog (SMOH) is a serpentine protein belonging to the G-protein coupled receptor Fz:Smo family with 787aa, seven transmembrane G protein-coupled receptors with 4 glycosylation sites and a putative extracellular amino terminus. Smoothened activated by b-Arrestin 2 and GRK2 acts as a receptor for Shh, the Sonic hedgehog gene product, and is a positive regulator of hedgehog signaling pathway along with the smoothened inhibitor patched protein (PTCH) and regulates vertebrate developmental processes, cellular proliferation and differentiation by activating transcription factor Gli. Smoothened mutants are known to cause sporadic basal cell carcinoma of the skin. It is known to express widely in heart and brain. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 0.1-1ug/ml Immunohistochemistry (paraffin): 10ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human heart lysate and human brain tissue Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S1014-63E
Reactivities: Human, Mouse, Non-Human Primate
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: Smoothened Homolog (Drosophila)
References: 1. Chen, W. et al. Science. 306:2257-2260 (2004). 2. Meloni, AR. et al. Mol. Cell. Biol. 26:7550-7560 (2006). 3. Xie, J. et al. Nature. 391:90-92 (1998).
Additional info: Recognizes human Smoothened Drosophila Homolog (SMOH). Species Crossreactivity: monkey and mouse. Species Sequence Homology: zebrafish

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