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Sm (Smith) Antigen

Cat no: S1014-25A

Supplier: United States Biological
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The sm (Smith) is an autoantigen on a series of particles composed of RNA and protein. Unlike RNP, the sm antigen is resistant to RNase, but partially sensitive to trypsin. It is involved in the pathogenesis of Systemic lupus erythematosus (SLE). Antibodies to sm are found in 20-30% of patients with SLE. Applications: Suitable for use in ELISA and Immunodiffusion. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: S1014-25A
Reactivities: Human
Applications: ELISA
Size: 2ml
Form: Supplied as a lyophilized powder from PBS, pH 7.2, 0.02% sodium azide. Reconstitute with 2ml sterile ddH2O.
P type: Pab
Isotype: IgG
Purity: Serum
Additional info: Recognizes human Sm antigen. Shows the Sm precipitate band when tested using double immunodiffusion against rabbit thymus extract. Anti-RNP precipitant is detected. Exhibits no reactivity when tested against purified SSB, Scl-70 and Jo-1 antigens. Anti-RNP and low levels of anti-SSA activity are detected.

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