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SLURP1, Secreted Ly-6/uPAR-related Protein 1

Cat no: S1014-67Q

Supplier: United States Biological
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Secreted Ly-6/uPAR-related protein 1, SLURP1, is a 9kD secreted member of the Ly-6/uPAR protein superfamily. Human SLURP1 is synthesized as a 103aa precursor that contains a 21aa signal sequence and an 82aa mature chain. Like other members of the Ly-6/uPAR family, SLURP1 contains a Ly-6/uPAR domain (aa24-73)and ten cysteine residues that make up five disulfide bonds. Unlike other family members, however, SLURP1 does not contain a GPI anchor. Mature human SLURP1 shares 67% and 68% aa identity with mouse and rat SLURP1, respectively. The protein forms a homodimer and is expressed in skin, eye, whole lung, trachea, esophagus, and stomach. In humans, SLURP1 is involved in maintaining the integrity of the kerotinocyte layers of the skin and has demonstrated antitumor activity. Applications: Suitable for use in Direct ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilution: Direct ELISA: 0.5-1ug/ml. The detection limit is ~5ng/lane. Immunohistochemistry: 25ug/ml Optimal dilutions to be determined by the researcher. Hybridoma: Myeloma cells with B cells from Balb/c mice. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: S1014-67Q
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Immunohistochemistry
Size: 100ug
Form: Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 200ul sterile PBS.
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein G affinity chromatography.
Additional info: Recognizes human SLURP1.

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