Home  >  Products  >  Slitrk2 (CXorf2, DKFZp451E1911, KIAA1854, MGC129912, MGC129913, SLIT and NTRK-like protein 2 precursor, SLITL1, UNQ9197/PRO34756)

Slitrk2 (CXorf2, DKFZp451E1911, KIAA1854, MGC129912, MGC129913, SLIT and NTRK-like protein 2 precursor, SLITL1, UNQ9197/PRO34756)

Cat no: S1014-18R1

Supplier: United States Biological
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SLIT and NTRK-like family 2 (Slitrk2) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains (1). Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk2 is expressed primarily in neurons in the ventricular layer of the brain (1,2). Like every other Slitrk protein except Slitrk1, overexpression of Slitrk2 inhibited neurite outgrowth in cultured neurons. Deletion analysis indicated that the functional difference between Slitrk2 and Slitrk1 is within their intracellular domains (1). At least two isoforms of this protein are known to exist. This antibody is predicted to have no cross-reactivity to other Slitrk proteins. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1
Catalogue number: S1014-18R1
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Aruga J and Mikoshiba K. Identification and characterization of Slitrk, a novel transmembrane protein family controlling neurite outgrowth. Mol. Cell Neurosci. 2003; 24:117-29. 2. Aruga J, Yokota N, and Mikoshiba K. Human SLITRK family genes: genomic organization and expression profiling in normal and brain tumor tissue. Gene 2003; 315:87-94.
Additional info: Recognizes human Slitrk2. Species crossreactivity: Mouse and rat.

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