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SKI (Sarcoma Viral Oncogene Homolog, Avian, c-SKI, SKV, v-Ski)

Cat no: S1013-89N

Supplier: United States Biological
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SKI is a nuclear protein that forms homodimers and heterodimers and binds to DNA to function as transcriptional activators and repressors. The SKI oncoprotein dramatically affects cell growth, differentiation, and/or survival. SKI was shown to act in distinct signaling pathways including those involving nuclear receptors, transforming growth factor beta, and tumor suppressors. SKI inhibits transforming growth factor-beta (TGF-beta) signaling through interaction with Smad proteins. SKI represses Smad-mediated transcriptional activation, probably through its action as a transcriptional co-repressor. SKI also inhibits TGF-beta-induced downregulation of genes such as c-myc. Applications: Suitable for use in Immunocytochemistry, Immunoprecipitation, and Western Blot. Other applications not tested. Recommended Dilution: Immunocytochemistry: 1-10ug/ml Western Blot: 1-5ug/ml Immunoprecipitation: 1-5ug Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: S1013-89N
Reactivities: Human, Mouse, Rat, Xenopus/Amphibian
Hosts: Mouse
Applications: Immunocytochemistry, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.4. No preservative added.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
References: 1. Tarapore, P., et al., (1997), Nucleic Acids Res., 25: 3895-3903. 2. Colmenares, C., et al., (1991), Molecular and Cellular Biology, 11: 1167-1170.
Additional info: Recognizes Ski protein. Species Crossreactivity: human, mouse, rat, chicken, Xenopus.

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