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SK2 (KCa2, Kcnn2, SKCa2+, Apamin-sensitive Small Conductance Ca2+ -dependent K+ Channel)

Cat no: S1014-09M1

Supplier: United States Biological
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Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for this gene. Applications: Suitable for use in ELISA and Western Blot. Other applications have not been tested. Recommended Dilutions: Peptide ELISA Titer: 1:64,000 Western Blot: 0.3-1ug/ml ~70kD and 23kD bands observed in Human Liver lysates (calculated MW of 63.8kD according to NP_067627.2 and of 26.3kD according to NP_740721.1). Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S1014-09M1
Reactivities: Human
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by peptide affinity chromatography.
Alternative names: small conductance calcium-activated potassium channel protein 2, apamin-sensitive small-conductance Ca2+-activated potassium channel, hSK2, SKCA2, SK2, KCa2.2, potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2, KCNN2
References: 1.Morimoto T, Ohya S, Hayashi H, Onozaki K, Imaizumi Y, Cell-cycle-dependent regulation of Ca2+-activated K+ channel in Jurkat T-lymphocyte.Journal of pharmacological sciences 2007 May 104(1): 94-8
Additional info: Recognizes human KCNN2. Species sequence homology: mouse, rat, canine, bovine.

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