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Sjogren Syndrome Antigen B (SSB, La autoantigen, Lupus La Protein)

Cat no: S1014-09F1


Supplier: United States Biological
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SSB is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. SSB protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome and systemic lupus erythematosus.La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III (see MIM 606007)-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome (MIM 270150) and systemic lupus erythematosus (SLE; MIM 152700) (Teplova et al., 2006). Applications: Suitable for use in ELISA and Immunodiffusion. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Reconstitute with sterile ddH2O, sterile 40-50% glycerol, aliquot and store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: S1014-09F1
Applications: ELISA
Size: 2ml
Form: Supplied as a lyophilized powder from 0.01M phosphate, 0.13M sodium chloride, pH 7.2, 0.02% sodium azide. Reconstitute with 2ml of deionized water.
P type: Pab
Purity: Purified by delipidization and defibrination.
Additional info: Recognizes human SSB antigen. Does not recognize purified Scl-70, Sm, Sm/RNP, and Jo-1 antigens. Anti-SSA activity is detected in this ELISA system.

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