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Sir2.1 (Silent Information Regulator 2)

Cat no: S1013-87K2

Supplier: United States Biological
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Sir2 (silent information regulator 2) protein plays a crucial role in regulating the life span of C. elegans by means of caloric restricion. Overexpression of the protein can extend the life span, and is, thus, a regulator of longevity. Applications: Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Immunohistochemistry (Frozen/paraffin): 1:200-1:500 Western Blot: 1:3000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S1013-87K2
Hosts: Rabbit
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Serum
References: 1. Wang, Y, et al. Mechan. of Age. and Dev. 127: 48/56 (2006). 2. Rizki G, Iwata TN, Li J, et al. The Evolutionarily Conserved Longevity Determinants HCF-1 and SIR-2.1/SIRT1 Collaborate to Regulate DAF-16/FOXO. PLoS Genet;7(9). 2011 Sep. [PMID: 21909281]
Additional info: Recognizes C. elegans Sir2.1 protein.

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