Home  >  Products  >  SIAH1 (Seven in Absentia Homolog 1 (Drosophila), SIAH 1, Siah-1, Siah-1a, E3 Ubiquitin-Protein Ligase SIAH1, hSIAH1, HUMSIAH, Ubiquitin Ligase SIAH1)
SIAH1 (Seven in Absentia Homolog 1 (Drosophila), SIAH 1, Siah-1, Siah-1a, E3 Ubiquitin-Protein Ligase SIAH1, hSIAH1, HUMSIAH, Ubiquitin Ligase SIAH1)

SIAH1 (Seven in Absentia Homolog 1 (Drosophila), SIAH 1, Siah-1, Siah-1a, E3 Ubiquitin-Protein Ligase SIAH1, hSIAH1, HUMSIAH, Ubiquitin Ligase SIAH1)

Cat no: S1013-31L8

Supplier: United States Biological
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SIAH1 (seven in absentia homolog 1 (Drosophila), also known as E3 ubiquitin-protein ligase, triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation and a cell surface receptor (DCC) amoungst others. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S1013-31L8
Reactivities: Human
Hosts: Goat
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris-saline, 0.02% sodium azide, 0.5% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Iwai, A. (2004) Siah-1L, a novel transcript variant belonging to the human Siah family of proteins, regulates beta-catenin activity in a p53-dependent manner. Oncogene. 23: 7593-7600. 2. Nagano, Y. et al (2003) Siah-1 facilitates ubiquitination and degradation of synphilin-1. J Biol Chem. 278: 51504-51514. 3. Hu, G. and Fearon, E.R. (1999) Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins. Mol Cell Biol. 19: 724-732. 4. Hu, G. (1997) Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway. Genes Dev. 11: 2701-2714.
Additional info: Recognizes human SIAH1.

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