Home  >  Products  >  SI-CLP (Stabilin-1-Interacting Chitinase-Like Protein, Chitinase Domain-Containing Protein 1, CHID1, GL008, PSEC0104, SB139)
SI-CLP (Stabilin-1-Interacting Chitinase-Like Protein, Chitinase Domain-Containing Protein 1, CHID1, GL008, PSEC0104, SB139)

SI-CLP (Stabilin-1-Interacting Chitinase-Like Protein, Chitinase Domain-Containing Protein 1, CHID1, GL008, PSEC0104, SB139)

Cat no: S7950-56

Supplier: United States Biological
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Stabilin-interacting chitinase like protein (SI-CLP), a novel member of the Glyco_18-domain containing protein family. SI-CLP is a secretory protein which is up-regulated in response to interleukin-4 and dexamethasone in alternatively activated macrophages. SI-CLP is also expressed by T- and B-lymphocytes, and by cells of monocytic and epithelial origin. SI-CLP is the ligand for stabilin-1, an intracellular sorting receptor which sorts SI-CLP into late endosomes and secretory lysosomes in activated macrophages. Applications: Suitable for use in Flow Cytometry, Immunofluorescence, and Western Blot. Other applications not tested. Recommended Dilutions: Flow Cytometry: 10ul labels 10e6 cells in 100ul Membrane permeabilisation is required. Western Blot: Detects a band at ~33 and 39kD in U937 cell lysates. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S7950-56
Reactivities: Human
Hosts: Rat
Applications: Flow Cytometry, Immunofluorescence, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein G affinity chromatography.
References: 1. Kzhyshkowska, J. et al. (2006) Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway. Blood. 107: 3221-3228. 2. Kzhyshkowska, J. et al. (2006) Stabilin-1, a homeostatic scavenger receptor with multiple functions. J. Cell. Mol. Med. 10: 635-649.
Additional info: Recognizes human SI-CLP.

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