Home  >  Products  >  SHP 2 (SHPTP-2, PTP2C, SH-PTP2, PTP1D, SH-PTP3, Syp, PTPN11)


Cat no: S1013-30A

Supplier: United States Biological
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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Applications: Suitable for use in ELISA and Western Blot. Other applications have not been tested. Recommended Dilutions: Peptide ELISA Titer: 1:32,000 Western Blot: 1-3ug/ml ~70kD band observed in Human Skeletal Muscle lysates and in lysates of cell line HEK293 (calculated MW of 68.0kD according to NP_002825.3). In transfected HEK293 transiently expressing PTPN11 bands of approx. 70kD and 49kD are observed. These bands are not observed in the non-transfected HEK293. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S1013-30A
Reactivities: Human
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by peptide affinity chromatography.
Alternative names: protein tyrosine phosphatase-2, MGC14433, protein tyrosine phosphatase, non-receptor type 11, protein-tyrosine phosphatase 2C, Noonan syndrome 1, SH-PTP3, SH-PTP2, PTP-1D, SHP-2, PTP2C, BPTP3, NS1, CFC, protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1), SHP2, PTPN11
References: 1. Takagi K, Takagi M, Kanangat S, Warrington KJ, Shigemitsu H, Postlethwaite AE. Modulation of TNF-alpha gene expression by IFN-gamma and pamidronate in murine macrophages: regulation by STAT1-dependent pathways. J Immunol. 2005 Feb 15;174(4):1801-10
Additional info: Recognizes human SHP2. Species sequence homology: mouse, rat, bovine.

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