Home  >  Products  >  SHP 2, phosphorylated (Ser582) (Protein tyrosine phosphatase, non-receptor type 11, SHPTP-2, PTP2C, SH-PTP2, PTP1D, SH-PTP3, Syp, PTPN11)

SHP 2, phosphorylated (Ser582) (Protein tyrosine phosphatase, non-receptor type 11, SHPTP-2, PTP2C, SH-PTP2, PTP1D, SH-PTP3, Syp, PTPN11)

Cat no: S1013-29K

Supplier: United States Biological
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SHP-2 (also called PTP2C, SH-PTP2, PTP1D, SH-PTP3, Syp and PTPN11) is a protein tyrosine phosphatase (PTP) expressed in most cell types (unlike SHP-1), (1). SHP-2 is involved in t the signal transduction stimulated by EGF, PDGF and Insulin. After cell stimulation, SHP-2 (as well as SHP-1), translocates from cytosol to the plasma membrane and binds to tyrosine-phosphorylated receptors through their SH2 domains, becoming activated in the process (2). When phosphorylated, SHP-2 has been shown to bind Grb2, EGFR, PDGFR, IRS-1 via its SH2 domain (3). Overexpression of SHP-2 leads to Juvenile Myelo-monocytic Leukemia and Noonan syndrome (4-5). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:25,000-1:50,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: S1013-29K
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
Alternative names: Protein-tyrosine phosphatase 2C, PTP-2C, PTP-1D, SH-PTP3, SH-PTP2, SHP-2, Shp2
References: 1. Ahmad, et al: Proc. Nat. Acad. Sci. 90: 2197-2201, 1993 2. Klingmu?ller, U., Lorentz, U., Cantley, L. C., Neel, BG. and Lodish, H. F. (1995) Cell 80, 729-738 3. Xiao et al (1994) J. Biol. Chem. 269, 21244-21248 4. Tartaglia et al.Hum. Genet. 70: 1555-1563, 2002. 5. Tartaglia et al. Nature Genet. 34: 148-150, 2003.
Additional info: Recognizes human SHP-2 phosphorylated at Tyrosine 582.

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