Home  >  Products  >  SHP 1 (SHP1, SHP-1, Hematopoietic Cell Protein-tyrosine Phosphatase, HCP, HCPH, Protein-tyrosine Phosphatase 1C, PTP1C, PTP-1C, HPTP1C, Protein-tyrosine Phosphatase SHP-1, SH-PTP1, SHP-1L, Tyrosine-protein Phosphatase Non-receptor Type 6, PTPN6)
SHP 1 (SHP1, SHP-1, Hematopoietic Cell Protein-tyrosine Phosphatase, HCP, HCPH, Protein-tyrosine Phosphatase 1C, PTP1C, PTP-1C, HPTP1C, Protein-tyrosine Phosphatase SHP-1, SH-PTP1, SHP-1L, Tyrosine-protein Phosphatase Non-receptor Type 6, PTPN6)

SHP 1 (SHP1, SHP-1, Hematopoietic Cell Protein-tyrosine Phosphatase, HCP, HCPH, Protein-tyrosine Phosphatase 1C, PTP1C, PTP-1C, HPTP1C, Protein-tyrosine Phosphatase SHP-1, SH-PTP1, SHP-1L, Tyrosine-protein Phosphatase Non-receptor Type 6, PTPN6)

Cat no: S1013-25M

Supplier: United States Biological
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SHP-1, an SH2 domain-containing protein tyrosine phosphatase, is primarily expressed in hematopoietic cells and behaves as a key regulator controlling intracellular phosphotyrosine levels in lymphocytes. SHP-1 has been proposed as a candidate tumor suppressor gene in lymphoma, leukemia and other cancers, as it functions as an antagonist to the growth-promoting and oncogenic potentials of tyrosine kinase. Dysfunction in SHP-1 regulation causes abnormal cell growth and induces different kinds of cancers. human SHP-1 gene is located on chromosome 12p13, consists of 17 exons and spans approximately 17 kb of DNA with a transcription size of 2.4
Catalogue number: S1013-25M
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 100ug
Form: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: Protein Tyrosine Phosphatase, Non-receptor Type 6, EC=3.1.3.48
References: 1. Chengyu, W. et al. Gene. 306:1-12 (2003).
Additional info: Recognizes human SHP-1. Species crossreactivity: mouse and rat.

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