Home  >  Products  >  SH3PXD2A (SH3 and PX Domain-containing Protein 2A, Adapter Protein TKS5, Five SH3 Domain-containing Protein, SH3 Multiple Domains Protein 1, Tyrosine Kinase Substrate with Five SH3 Domains, FISH, KIAA0418, SH3MD1, TKS5)
SH3PXD2A (SH3 and PX Domain-containing Protein 2A, Adapter Protein TKS5, Five SH3 Domain-containing Protein, SH3 Multiple Domains Protein 1, Tyrosine Kinase Substrate with Five SH3 Domains, FISH, KIAA0418, SH3MD1, TKS5)

SH3PXD2A (SH3 and PX Domain-containing Protein 2A, Adapter Protein TKS5, Five SH3 Domain-containing Protein, SH3 Multiple Domains Protein 1, Tyrosine Kinase Substrate with Five SH3 Domains, FISH, KIAA0418, SH3MD1, TKS5)

Cat no: S1013-33V

Supplier: United States Biological
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Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 3.75-7.5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S1013-33V
Reactivities: Human
Hosts: Goat
Applications: Immunohistochemistry
Size: 50ug
Form: Supplied as a liquid in Tris saline buffer, pH 7.3, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
Additional info: Recognizes human SH3PXD2A.

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