FOLR4 (folate receptor 4; also FR4, FR-delta and FOLBP-3) is a 35kD glycoprotein member of the folate receptor family. It is found on mouse Treg cells, particularly those classified as natural and CD4+ CD25- T cells that produce low amounts of IFN-gamma. Its function is unclear. Although folate family receptors can internalize folate, they are generally not the principal conduits for folate uptake. Mouse FOLR4 preproprecursor is 244aa in length. It contains a 19aa signal sequence plus a 225aa proform. While there are no definitive structural motifs, there is presumably a C-terminal propeptide that gives rise to a GPI-linkage. There are three potential isoforms. One is 37kD in size and shows a 36aa insertion after Glu155. Two others show a deletion of aa47-109, and a 17aa substitution foraa157-244. Over aa20-100, mouse FOLR4 shares 84% and 70% aa identity with rat and human FOLR4, respectively.
Applications:
Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilutions:
ELISA: 0.5-1ug/ml
Western Blot: 1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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