Casein Kinase 2 beta, phosphorylated (Ser209) (Protein Kinase CK2, PKCK2, CK2b, CK2 beta, CKIIb, CK2B1, CSNK2B1)

Protein kinase CK2 or PKCK2 (formerly known as casein kinase 2) is a serine/threonine kinase, and consists of two constitutively active catalytic (a and a

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SPECIFICATIONS

Catalog Number

C2085-72F

Size

10 Blots

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS (without Mg2+ and Ca2+), 1mg/ml BSA (IgG, protease free), pH 7.2, 0.05% sodium azide, 50% glycerol.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

References

1. Miyata, Y. and E. Nishida (2004) CK2 controls multiple protein kinases by phosphorylating a\nkinase-targeting molecular chaperone, Cdc37. Mol. Cell. Biol. 24(9):4065-4074. 2. Lee, G., et al. (2004) Casein kinase II-mediated phosphorylation regulates alpha-synuclein/synphilin-1 interaction and inclusion body formation. J. Biol. Chem. 279(8):6834-6839. Akten, B., et al. (2003) A role for CK2 in the Drosophila circadian oscillator. Nat. Neurosci. 6(3):251-257. 3. Kawaguchi, Y., et al. (2003) Conserved protein kinases encoded by herpesviruses and cellular protein kinase cdc2 target the same phosphorylation site in eukaryotic elongation factor 1delta. J. Virol. 77(4):2359-2368.\n4. Provost, E., et al. (2003) Functional correlates of mutations in beta-catenin exon 3 phosphorylation sites. J. Biol. Chem. 278(34):31781-31789. 5. D. W. Litchfield (2003) Protein kinase CK2: structure, regulation and role in cellular decisions of life and death. Biochem. J. 369(Pt 1):1-15. Review. 6. Meggio, F. and L.A. Pinna (2003) One-thousand-and-one substrates of protein kinase CK2? FASEB J. 17(3):349-368. Review. 7. Sarno, S., et al. (2002) Toward the rational design of protein kinase casein kinase-2 inhibitors. Pharmacol. Ther. 93(2-3):159-168. Review. 8. Litchfield, D.W., et al. (1995) The protein kinase from mitotic human cells that phosphorylates Ser-209 on the casein kinase II beta-subunit is p34cdc2. Biochim. Biophys. Acta. 1269(1):69-78.

Additional Info

Recognizes human CK2b when phosphorylated at Ser209. Species sequence homology: Other species CK2b (100%). Does not cross react with CK2a [pS360] (mouse), [pS362], [pS370], or CK2b [pS2].