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Troponin I, Cardiac (cTnI, CMH7, Familial Hypertrophic Cardiomyopathy 7, MGC116817, TNNC1, Troponin I Type 3 Cardiac, TNNI3)

Cat no: T8665-16E


Supplier: United States Biological
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Troponin, working in conjunction with tropomyosin, functions as a molecular switch, regulating muscle contraction in response to changes in the intracellular Ca2+ concentration. Troponin consists of three subunits, the Ca2+-binding subunit troponin C (TnC), the tropomyosin-binding subunit troponin T (TnT), and the inhibitory subunit troponin I (TnI). Troponin I binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place Because of which myosin can not bind the actin in relaxed muscle. When Calcium binds to the Troponin C it causes certain confirmational changes which leads to dislocation of troponin I and finally tropomyosin leaves the the binding site for myosin on actin leading to contraction of muscle. The letter I is given due to its inhibitory character. Applications: Suitable for use in Western Blot and Sandwich ELISA. Other applications not tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher. Hybridoma: Sp2/0 myeloma cells with spleen cells of Balb/c mice. Recommended Pairs: Detection: T8665-19B: Troponin I, Cardiac, aa41-49 T8665-16R: Troponin I, Cardiac, aa169-178 Capture: T8665-16E: Troponin I, Cardiac Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8665-16E
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Western Blot
Size: 1mg
Form: Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein A affinity chromatography. >90% (SDS-PAGE).
Additional info: Recognizes free human cardiac troponin I (cTnl) and cTnl-forming complexes with other troponin components. Not effected by heparin, phosphorylation or oxidation. Recognizes an epitope located between aa83-93 of cTnI. No crossreactivity with skeletal muscle troponin I.

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