Home  >  Products  >  Troponin C, Cardiac (Cardiac Troponin C, CMH7, cTnI, Slow Troponin C1, Troponin C Slow, Troponin C Slow Skeletal and Cardiac Muscles, TN C, TNC, TN-C, TNNC, Troponin C Type 1 (Slow), Troponin C1 Slow, TNNC 1, TNNC1, TNNC1 Protein, Troponin I Type 3 (Cardi
Troponin C, Cardiac (Cardiac Troponin C, CMH7, cTnI, Slow Troponin C1, Troponin C Slow, Troponin C Slow Skeletal and Cardiac Muscles, TN C, TNC, TN-C, TNNC, Troponin C Type 1 (Slow), Troponin C1 Slow, TNNC 1, TNNC1, TNNC1 Protein, Troponin I Type 3 (Cardi

Troponin C, Cardiac (Cardiac Troponin C, CMH7, cTnI, Slow Troponin C1, Troponin C Slow, Troponin C Slow Skeletal and Cardiac Muscles, TN C, TNC, TN-C, TNNC, Troponin C Type 1 (Slow), Troponin C1 Slow, TNNC 1, TNNC1, TNNC1 Protein, Troponin I Type 3 (Cardi

Cat no: T8665-01A

Supplier: United States Biological
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Troponin (Tn) is the central regulatory protein of striated muscle contraction. Tn consists of three components: TnI which is the inhibitor of actomyosin ATPase, TnT which contains the binding site for tropomyosin and TnC. The binding of calcium to TnC abolishes the inhibitory action of Tn on actin filaments, and as a result of calcium ion uptake by troponin C, the elements of the muscle thin filament undergo a series of allosteric changes which allow the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Applications: Suitable for use in ELISA, Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8665-01A
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Immunoprecipitation, Western Blot
Size: 200ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.
P type: Mab
Isotype: IgG2b
Purity: Purified by Protein A affinity chromatography.
References: 1. Sarko, J. & Pollack, C.V., Cardiac troponins. J Emerg Med 23:57-65 (2002). 2. Gomes, A.V. et al. . IUBMB Life 54:323-33 (2002). 3. Hamm, C.W., Thromb Res 103 Suppl 1:S63-9 (2001). 4. Labugger, R. et al. E Circulation 102:1221-6 (2000). 5. Wu, A.H. et al. Characterization of cardiac troponin subunit release into serum after acute myocardial infarction and comparison of assays for troponin T and I. American Association for Clinical Chemistry Subcommittee on cTnI Standardization. Clin Chem 44:1198-208 (1998). 6. Katrukha, A.G. et al. Troponin I is released in bloodstream of patients with acute myocardial infarction not in free form but as complex. Clin Chem 43:1379-85 (1997).
Additional info: Recognizes human Troponin C at ~19kD.

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