Home  >  Products  >  Transportin 1 (Transportin-1, Transportin1, TNPO1, Importin beta 2, IPO2, Karyopherin (Importin) beta 2, Karyopherin beta 2, KPNB2, M9 Interacting Protein, M9-interacting Protein, MIP 1, MIP1, MIP-1, M9 Region-interacting Protein, M9 Region Interaction Pr
Transportin 1 (Transportin-1, Transportin1, TNPO1, Importin beta 2, IPO2, Karyopherin (Importin) beta 2, Karyopherin beta 2, KPNB2, M9 Interacting Protein, M9-interacting Protein, MIP 1, MIP1, MIP-1, M9 Region-interacting Protein, M9 Region Interaction Pr

Transportin 1 (Transportin-1, Transportin1, TNPO1, Importin beta 2, IPO2, Karyopherin (Importin) beta 2, Karyopherin beta 2, KPNB2, M9 Interacting Protein, M9-interacting Protein, MIP 1, MIP1, MIP-1, M9 Region-interacting Protein, M9 Region Interaction Pr

Cat no: T8266-10

Supplier: United States Biological
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Heterogeneous nuclear ribonucleoprotein hnRNPA1 is an abundant nuclear protein that plays an important role in pre-mRNA processing and mRNA export from the nucleus. A1 shuttles rapidly between the nucleus and the cytoplasm, and a 38-amino acid domain, M9, serves as the bi-directional transport signal of A1. Recently, a 90kD protein, transportin, was identified as the mediator of A1 nuclear import. Transportin mediates the nuclear import of additional hnRNP proteins, including hnRNPF. The nuclear localization of A1 is dependent on ongoing RNA polymerase II transcription. Applications: Suitable for use in Immunofluorescence, ELISA, Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Cellular Localization: Cytoplasm, nucleoplasm and nuclear rim. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 3 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: T8266-10
Reactivities: Human, Non-Human Primate, Rabbit
Hosts: Mouse
Applications: ELISA, Immunofluorescence, Immunoprecipitation, Western Blot
Size: 50ul
Form: Supplied as a liquid in PBS, pH 7.2.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
References: Siomi MC et al. Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins. J Cell Biol 138:1181-92 (1997).
Additional info: Species Crossreactivity: Crossreacts with Human, Monkey and Rabbit. Not yet tested in other species.

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