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Transforming Growth Factor beta1, beta2, beta3 (TGFb1, TGFb2, TGFb3) (PE)

Cat no: T8250-19B

Supplier: United States Biological
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Transforming Growth Factor Beta (TGF-beta) is a stable, multifunctional polypeptide growth factor. While specific receptors for this protein have been found on almost all mammalian cell types thus far examined, the effect of the molecule varies depending on the cell type and growth conditions. Generally, TGF-beta is stimulatory for cells of mesenchymal origin and inhibitory for cells of epithelial or neuroectodermal origin. It is now known that the originally described form of TGF-beta, now described as TGF-beta1, is only one of a family of regulatory proteins consisting of a number of proteins distantly related to TGF-beta1 (30-40% sequence homology) and a number of more closely related proteins (70-80% sequence homology) designated TGF-beta2, TGF-beta1.2, TGF-beta3, TGF-beta4, and TGF-beta5. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: 10ul labels 1x10e6 cells Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C as an undiluted liquid. Stable for 12 months at 4 degrees C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.
Catalogue number: T8250-19B
Reactivities: Human, Mouse, Bovine, Chicken/Bird
Hosts: Mouse
Applications: Flow Cytometry
Size: 100Tests
Form: Supplied as a liquid in saline, 0.5% BSA, 0.1% sodium azide. Labeled with R-Phycoerythrin (PE).
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
Additional info: Recognizes bovine TGFb1 and TGFb2. Species Crossreactivity: mouse TGFb1 and TGFb2; human TGFb1, recombinant human TGFb2 and recombinant human TGFb3; recombinant chicken TGFb3; recombinant avian TGFb5.

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