Home  >  Products  >  TLR1 (Toll Like Receptor 1, Toll-like Receptor 1 Precursor, CD281, CD281 Antigen, DKFZp547I0610, DKFZp564I0682, KIAA0012, MGC104956, MGC126311, MGC126312, rsc786, Similar to Drosophila Toll Protein, TIL, Toll (Drosophila) Homolog, Toll/Interleukin 1 Recep

TLR1 (Toll Like Receptor 1, Toll-like Receptor 1 Precursor, CD281, CD281 Antigen, DKFZp547I0610, DKFZp564I0682, KIAA0012, MGC104956, MGC126311, MGC126312, rsc786, Similar to Drosophila Toll Protein, TIL, Toll (Drosophila) Homolog, Toll/Interleukin 1 Recep

Cat no: T8050-01G


Supplier: United States Biological
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Toll-like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defence to many pathogens. In Drosophila Toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defences. In mammals, TLR identified as type I transmembrane signalling receptors with pattern recognition capabilities, have been implicated in the innate host defence to pathogens. Mammalian responsiveness to some bacterial products may be mediated by combinations of TLRs, for example a co-operative effect is observed between TLR1 (CD281) and TLR2 (CD282). TLR1 is expressed by monocytes and dendritic cells. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. FITC conjugates are sensitive to light.
Catalogue number: T8050-01G
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry
Size: 100ug
Form: Supplied as a liquid in PBS, 1% BSA, 0.02% sodium azide. Labeled with fluorescein isothiocyanate (FITC).
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
Alternative names: Toll-like receptor 1, CD281
References: 1. Wyllie, D et al; Evidence for an accessory protein function for Toll-like receptor 1 in anti-bacterial responses. J Immunol 2000, 165: 7125 2. Visintin, A et al; Regulation of Toll-like receptors in human monocytes and dendritic cells. J Immunol 2001, 166:249
Additional info: Recognizes human TLR1. Does not recognizes TLR2, TLR4 (CD284) or TLR4 in association with MD2.

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