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TLR Adaptor, Antibody Sampler Set, BioAssay(TM)

Cat no: T8049-90

Supplier: United States Biological
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Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules to activate various kinases and transcription factors so the organism can respond to potential infection. These adaptor molecules include MyD88, TIRAP, TIRP, TOLLIP, and TRIF. These molecules interact with and activate the IL-1R-associated kinase (IRAK) family, which then activates TNF receptor associated factor (TRAF)-6, and ultimately leads to the activation of NF-kB. While most TLRs utilize more than one adaptor, certain adaptor molecules are essential for individual TLR signaling, e.g., TLR4 signaling is dependent on TIRP expression. Rabbit polyclonal antibodies were raised against peptide sequences corresponding to each of the target proteins. Kit Components: MyD88, ID (Rb x Hu): 1x25ug TIRAP, CT (Rb x Hu): 1x25ug TIRP (Rb x Hu): 1x25ug TOLLIP (Rb x Hu): 1x25ug TRIF (Rb x Hu): 1x25ug Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1-4ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8049-90
Size: 1 Set
Form: Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide.
References: 1. Takeda, K. et al. Annu. Rev. Immunol. 21, 335 (2003). 2. Janeway, CA Jr. et al. Annu. Rev. Immunol. 20, 197 (2002). 3. McGettrick, AF. et al. Mol. Imm. 41, 577 (2004).

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