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Survivin (TIAP, API4)

Cat no: S8500-08A

Supplier: United States Biological
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Survivin is a 16kD apoptosis inhibitor protein (IAP). It binds and inhibits the caspase-3 proteolytic activity and controls the checkpoint in the G2/M phase of the cell cycle to promote cell division by the control of microtubule stability and assembly of a normal mitotic spindle. Survivin is highly expressed during fetal development, transformed cell lines, human cancers and non-Hodgkin's lymphomas. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:50 Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: S8500-08A
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 1mg
Form: Supplied as a liquid in PBS, pH 7.2.
P type: Pab
Purity: Purified by Protein G affinity chromatography.
References: Ambrosini, G. et al. (1997) Nat. Med. 3,917-921. Li, F. et al. (1998) Nature 396,580-584. Verhagen, A.M. et al. (2001) Genome Biol. 2,3009.1-3009.10. Giodini, A. et al. (2002) Cancer Res. 62,2462-2467. Ryan, B.M. et al. (2006) Ann. Oncol. 17,597-604.
Additional info: Recognizes human Survivin

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