Home  >  Products  >  Survival of Motor Neuron 1, Telomeric (Survival of Motor Neuron 1 (Telomeric), SMNT, Survival of Motor Neuron 1, Survival Motor Neuron 1 Protein, SMN1, BCD541, Component of Gems 1, Gemin 1, Gemin-1, SMA, SMA@, SMA1, SMA2, SMA3, SMA4, SMNC, Survival Motor

Survival of Motor Neuron 1, Telomeric (Survival of Motor Neuron 1 (Telomeric), SMNT, Survival of Motor Neuron 1, Survival Motor Neuron 1 Protein, SMN1, BCD541, Component of Gems 1, Gemin 1, Gemin-1, SMA, SMA@, SMA1, SMA2, SMA3, SMA4, SMNC, Survival Motor

Cat no: S8495-03


Supplier: United States Biological
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Survival of Motor Neuron 1 (SMN, Germin 1) is the central component of a large oligomeric complex (SMN complex), including Gemins 2-7, that is necessary and sufficient for the in vivo assembly of Sm proteins onto the small nuclear (sn)RNAs that mediate pre-mRNA splicing. The SMN complex is found in the cytoplasm and nucleus. Within the nucleus, this protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). Spinal muscular atrophy, a motor neuron disorder, results from reduced levels or a mutation in the Gemin 1 protein. Applications: Suitable for use in Western Blot, Immunoprecipitation and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: A431 whole cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S8495-03
Reactivities: Human, Mouse, Xenopus/Amphibian
Hosts: Mouse
Applications: Immunocytochemistry, Immunoprecipitation, Western Blot
Size: 50ul
Form: Supplied as a liquid in PBS, pH 7.4, 15mM sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified
References: 1. Liu, Q., et al., EMBO J. 15: 3555-3565 (1996). 2. Charroux, B., et al., J. Cell Biol. 147: 1181-1193 (1999). 3. Paushkin, S., et al., Curr. Opin. Cell Biol. 14: 305-312 (2002). 4. Pellizzoni, L., et al., Proc. Natl. Acad. Sci. USA 96: 11,167-11,172 (1999). 5. Baccon, J., et al., J. Biol. Chem. 277: 31,957-31,962 (2002). 6. Pellizzoni, L., Science 298: 1775-1779 (2002).
Additional info: Recognizes human Survival of Motor Neuron 1, Telomeric at ~35kD. Species Crossreactivity: Mouse, Xenopus laevis

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