SOD1 destroys radicals which are normally produced within cells and which are toxic to biological systems by catalysing the dismutation of superoxide into oxygen and hydrogen peroxide. Copper and Zinc are its cofactors. It is a homodimer that localises to the cytoplasm. Defects in SOD1 are the cause of amyotrophic lateral sclerosis (ALS1) which is a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis.
Applications:
Suitable for use in ELISA. Other applications not tested.
Recommended Dilution:
Optimal dilutions to be determined by the researcher.
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile 40-50% glycerol, ddH2O. Reconstituted product is stable for 12 months at -20 degrees C. Aliquot and store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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