Home  >  Products  >  Stathmin 1, phosphorylated (Ser24) (Stathmin-1, STMN1, Stathmin, SMN, Lag, Leukemia-associated Phosphoprotein p18, LAP18, Metablastin, Oncoprotein 18, OP18, p18, p19, Phosphoprotein 19, Phosphoprotein p19, PP17, PP19, PR22, Pr22 Protein, Prosolin, Protein

Stathmin 1, phosphorylated (Ser24) (Stathmin-1, STMN1, Stathmin, SMN, Lag, Leukemia-associated Phosphoprotein p18, LAP18, Metablastin, Oncoprotein 18, OP18, p18, p19, Phosphoprotein 19, Phosphoprotein p19, PP17, PP19, PR22, Pr22 Protein, Prosolin, Protein

Cat no: S7972-50R


Supplier: United States Biological
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Oncoprotein 18 (Op18) is a proliferation-related cytosolic phosphoprotein which is induced in normal lymphocytes following mitogenic stimulation. Studies of Op18 are of particular interest because of the proposed role it plays in signal transduction and because of its occurrence in markedly increased amounts in acute leukemia cells (1). Oncoprotein 18 has been independently identified due to its increased phosphorylation in response to external signals and its up-regulated expression in acute leukemia. Findings suggest that Op18 may be a physiological substrate for several members of the cdc2 kinase family during both the S-phase and the mitotic phase of the cell cycle (2). Also, findings show that Op18 by itself can fold into a flexible and extended alpha-helix, which is in equilibrium with a less ordered structure. In complex with tubulin, however, all except the last seven C-terminal residues of Op18 are tightly bound to tubulin. Studies suggest results suggest that besides sequestering tubulin, the structural features of Op18 enable the protein specifically to recognize microtubule ends to trigger catastrophes (3). Applications: Suitable for use in Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:500 Immunocytochemistry: 1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: S7972-50R
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunocytochemistry, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50 mM Tris-Glycine, pH 7.4, 0.15 M sodium chloride, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
Alternative names: Phosphoprotein p19, pp19, Oncoprotein 18, Op18, Leukemia-associated phosphoprotein p18, pp17, Prosolin, Metablastin, Protein Pr22
References: 1. Melhem RF, et al. J Biol Chem 266(27):17747-53, 1991 2. Brattsand G, et al. Eur J Biochem 220(2):359-68, 1994 3. Steinmetz MO, et al. EMBO J 19(4):572-80, 2000
Additional info: Recognizes human Op18 phosphorylated at Serine 24. Species crossreactivity: mouse and rat.

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