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Sptan1 (Spectrin alpha Chain, Non-erythrocytic 1, Alpha-II Spectrin, Fodrin alpha Chain, Spna2, Spta2)

Cat no: S5381-04A

Supplier: United States Biological
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Fodrin is a universally expressed membrane-associated cytoskeletal protein consisting of a- and b-subunits. The protein is important for maintaining normal membrane structure and supporting cell surface protein function. a-Fodrin is one of the important targets cleaved by caspases during apoptosis. The full length 240kD protein can be cleaved at several sites within its sequence by activated caspases generating N-terminal 150kD, C-terminal 120kD, and 35kD major products. Cleavage of a-Fodrin leads to membrane malfunction and cell shrinkage Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-4ug/ml Immunohistochemistry: 10-20ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S5381-04A
Reactivities: Human, Mouse, Rat, Chicken/Bird
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.5% BSA, 0.01% thimerosal, 30% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by affinity chromatography.
Additional info: Recognizes mouse alpha-Fodrin. Species Crossreactivity: human, rat and chicken.

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