SST2 is a Somatostatin receptor. Somatostatin negatively regulates the growth of various normal and tumor cells via five somatostatin receptors. Somatostatin receptors are expressed by a large variety of human tumors, and the predominant expression of SST2 receptors in tumor tissues forms the basis for the successful application of SST2-preferring agonists in the treatment of patients with GH-secreting pituitary adenomas, as well as in patients with carcinoid or islet cell tumors. The SST2 receptor exists as two splice variants that differ in length and composition of their intracellular carboxy termini. SST2 is the only member of the somatostatin receptor family that contains introns. SST2 expression has been reported in adrenal, aorta, brain, breast, eye, gastrointestinal tract, pancreas, prostate, spinal cord, and thyroid. ESTs have been isolated from brain, eye, head/neck, kidney, lymph node, pineal, and prostate libraries.
Applications:
Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended Dilution:
Immunohistochemistry (paraffin): 24ug/ml
Optimal dilutions to be determined by the researcher.
Positive Control:
Human Pancreas, Islet of Langerhans
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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