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SNX2 (Sorting Nexin 2, Sorting Nexin-2, MGC5204, Transformation-related Gene 9 Protein, TRG9, TRG-9)

SNX2 (Sorting Nexin 2, Sorting Nexin-2, MGC5204, Transformation-related Gene 9 Protein, TRG9, TRG-9)

Cat no: S1014-97B2

Supplier: United States Biological
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Snx2 is a signaling protein belonging to the sorting nexin family and characterized by the presence of a 100aa region known as the phox (PX) homology domain (a phosphoinositide binding domain). As a transport carrier Snx2 is involved in several stages of intracellular trafficking of proteins and also in the EGFR signaling pathway. The retromer complex that is composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, Snx1 and Snx2, is required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Though Snx2 associates with formin-binding protein 17, its function is yet unknown. It may form oligomeric complexes with itself as well as with other family members Snx1, Snx1A, and Snx4, but not with Snx3 and is ubiquitously expressed in most tissues, including peripheral leukocytes. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.1-0.5ug/ml Immunohistochemistry (formalin fixed paraffin embedded): 5ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Mouse Placenta lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S1014-97B2
Reactivities: Human, Mouse, Bovine, Canine
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Rojas, R. et al. Mol. Cell Biol. 27:1112-1124 (2007). 2. Carlton, JG. et al. J. Cell. Sci. 118:4527-4539 (2005). 3. Haft, CR. et al. Molec. Cell. Biol. 18:7278-7287 (1998).
Additional info: Recognizes human Snx2. Species Crossreactivity: chimpanzee, bovine, canine, mouse, opossum. Species sequence homology: equine.

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