Home  >  Products  >  SMAD5 (Mothers Against Decapentaplegic Homolog 5, MAD Homolog 5, Mothers Against DPP Homolog 5, JV5-1, SMAD Family Member 5, SMAD 5, hSmad5, MADH5)

SMAD5 (Mothers Against Decapentaplegic Homolog 5, MAD Homolog 5, Mothers Against DPP Homolog 5, JV5-1, SMAD Family Member 5, SMAD 5, hSmad5, MADH5)

Cat no: S1014-55G6


Supplier: United States Biological
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Smad proteins, the mammalian homologs of the Drosophila Mothers against dpp (Mad), have been implicated as downstream effectors of TGFb/BMP signaling. Smad1, Smad5, and Smad8 are effectors of BMP2 and BMP4 function while Smad2 and Smad3 are involved in TGF-b and activin-mediated growth modulation. Smad4 has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to activin/TGFb signaling by interfering with TGFb-mediated phosphorylation of other Smad family members. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-4ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S1014-55G6
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 1% BSA, 0.02% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by affinity chromatography.
Additional info: Recognizes human Smad5 at ~60kD. Species Crossreactivity: mouse and rat.

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