Home  >  Products  >  SLP-76 (LCP2, lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) Lymphocyte cytosolic protein 2, SH2 domain-containing leucocyte protein of 76kD, SH2 domain-containing leukocyte protein of 76kD,SLP-76 tyrosine phosphoprotein

SLP-76 (LCP2, lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) Lymphocyte cytosolic protein 2, SH2 domain-containing leucocyte protein of 76kD, SH2 domain-containing leukocyte protein of 76kD,SLP-76 tyrosine phosphoprotein

Cat no: S1014-20R


Supplier: United States Biological
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SLP-76 is a 533aa, 76kD tyrosine phosphorylated intracellular docking protein with a single SH2 recognition domain. It is expressed in T cells, platelets, neutrophils, NK and mast cells, and is required for progression of T cells to double positive stage in the thymus. Tyrosine phosphorylation is required for interaction with the signaling proteins VAV, NCK, PLCg, ITK, and ZAP70. SLP-76 may be phosphorylated by ZAP70 leading to NF-AT and IL2 gene activation. Human SLP-76 shares 83% and 85% aa sequence identity with mouse and rat SLP-76, respectively. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1.0ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile 40-50% glycerol, PBS.. Aliquot and store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: S1014-20R
Reactivities: Human
Hosts: Mouse
Applications: Western Blot
Size: 100ug
Form: Supplied as a lyophilized powder in 0.2um sterile-filtered solution PBS, 5% trehalose. Reconstitute with 40-50% glycerol, PBS.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
Additional info: Recognizes human SLP-76 at ~90kD.

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