Home  >  Products  >  SIRT1, phosphorylated (Ser27) (SIRT1 Sir2-like Proteins (Sirtuins) Type 1, Sirtuin, Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 1 (S. cerevisiae), Sirtuin Type 1, BA57G10.4, hSIRT1, NAD-dependent Deacetylase SIRT1, NAD-dependent Deacetyl

SIRT1, phosphorylated (Ser27) (SIRT1 Sir2-like Proteins (Sirtuins) Type 1, Sirtuin, Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 1 (S. cerevisiae), Sirtuin Type 1, BA57G10.4, hSIRT1, NAD-dependent Deacetylase SIRT1, NAD-dependent Deacetyl

Cat no: S1013-88G2


Supplier: United States Biological
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The S. cerevisiae silent information regulator 2 (Sir2) protein is an NAD+-dependent histone deacetylase (HDACs) that plays a critical role in transcriptional silencing, genome stability, and longevity (1-2). Part of the Sirtuin family (Sir2, Sir3, Sir3), yeast Sir2 is the founding member of Class III HDACs. A human homologue of Sir2, SIRT1, regulates the activity of the p53 tumor suppressor and inhibits apoptosis (3-4). Applications: Suitable for use in Western Blotting, Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:1000-1:10,000 Immunoprecipitation: 1:20 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: S1013-88G2
Reactivities: Human
Hosts: Rabbit
Applications: Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
Alternative names: SIR2-like protein 1, hSIR2
References: 1. David A. Sinclair et al; J. Biol. Chem., Vol. 277, Issue 47, 45099-45107, November 22, 2002 2. Smith, J. Set al. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 6658-6663 3. Kouzarides et al, EMBO Journal, Vol. 21, No. 10 pp. 2383- 2396, 2002 4. Tanner, K. G.et al (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 14178-1418288: 900
Additional info: Recognizes human Sir2/SIRT1 phosphorylated on serine 27.

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