Home  >  Products  >  SIRT 4 (Sirtuin 4, Sirtuin-4, Sirtuin Type 4, MGC57437, MGC130046, MGC130047, NAD-dependent ADP-ribosyltransferase Sirtuin-4, Sir2 Like 4, Sir2-like 4, SIR2 Like Protein 4, SIR2-like Protein 4, SIR2L4)
SIRT 4 (Sirtuin 4, Sirtuin-4, Sirtuin Type 4, MGC57437, MGC130046, MGC130047, NAD-dependent ADP-ribosyltransferase Sirtuin-4, Sir2 Like 4, Sir2-like 4, SIR2 Like Protein 4, SIR2-like Protein 4, SIR2L4)

SIRT 4 (Sirtuin 4, Sirtuin-4, Sirtuin Type 4, MGC57437, MGC130046, MGC130047, NAD-dependent ADP-ribosyltransferase Sirtuin-4, Sir2 Like 4, Sir2-like 4, SIR2 Like Protein 4, SIR2-like Protein 4, SIR2L4)

Cat no: S1013-88H4

Supplier: United States Biological
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SIRT4, otherwise known as sirtuin 4, is a mitochondrial NAD-dependent ADP-ribosyl transferase, and member of the sirtuin family, which catalyzes the transfer of ADP-ribosyl groups onto target proteins. Studies have shown that SIRT4 acts as a repressor of GDH (glutamate dehydrogenase) activity in beta cell mitochondria, thereby suppressing amino-acid dependent insulin production. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-3ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human Kidney lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S1013-88H4
Reactivities: Human
Hosts: Goat
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 4 (S. cerevisiae), EC=2.4.2.-, NAD-dependent Deacetylase Sirtuin 4, Silent Mating Type Information Regulation 2 Homolog
References: 1. Frye RA. Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity.Biochem Biophys Res Commun. 1999 Jun 24;260(1):273-9.PMID: 10381378
Additional info: Recognizes human SIRT4. Species sequence homology: mouse and rat.

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