Home  >  Products  >  Ryanodine Receptor (RyR, RYDR, ARVC2, ARVD2, Brain Ryanodine Receptor Calcium Release Channel, Brain-type Ryanodine Receptor, Cardiac Muscle Ryanodine Receptor, Cardiac Muscle Ryanodine Receptor Calcium Release Channel, Cardiac Muscle Type Ryanodine Recep

Ryanodine Receptor (RyR, RYDR, ARVC2, ARVD2, Brain Ryanodine Receptor Calcium Release Channel, Brain-type Ryanodine Receptor, Cardiac Muscle Ryanodine Receptor, Cardiac Muscle Ryanodine Receptor Calcium Release Channel, Cardiac Muscle Type Ryanodine Recep

Cat no: R9950-05A


Supplier: United States Biological
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The Ryanodine Receptor (RyR) is the channel responsible for calcium release from muscle cell Sarcoplasmic Reticulum (SR) and also plays a role in calcium regulation in non-muscle cells. The RyR exists as a homotetramer and is predicted to have a short cytoplasmic C-terminus and 4-10 transmembrane domains. The remainder of the protein, termed the "foot" region, is located in the cytoplasm between the transverse tubule and the SR. Mammalian RyR isoforms are the product of three different genes: RyR-1 is expressed predominantly in skeletal muscle and areas of the brain; RyR-2 is expressed predominantly in heart muscle but also found in the stomach, endothelial cells and diffuse areas of the brain; and RyR-3 is found in smooth muscle and the brain (striatum, thalamus and hippocampus). In non-mammalian vertebrates, the RyR isoforms are termed alpha, beta and cardiac which correlate loosely to the mammalian RyR-1, RyR-3 and RyR-2 isoforms respectively. Applications: Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Immunohistochemistry: Frozen Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: R9950-05A
Reactivities: Human, Mouse, Rat, Bovine, Canine, Chicken/Bird, Rabbit, Sheep
Hosts: Mouse
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in PBS, pH 7.2, 0.05% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Ascites
References: 1. Liu Z et al. Proc Natl Acad Sci U S A 98:6104-9 (2001). 2. Chan SL et al. J Biol Chem 275:18195-200 (2000). 3. Yamada KA et al. J Cardiovasc Pharmacol 36:14-21 (2000). 4. Moore RA et al. J Cell Biol 140:843-51 (1998). 5. Protasi F et al. J Cell Biol 140:831-42 (1998). 6. Liu G & Pessah J Biol Chem 269:33028-34 (1994). 7. Chen SR et al. J Biol Chem 268:22642-9 (1993). 8. Airey JA et al. Biochemistry 32:5739-45 (1993). 9. Walton PD et al. J Cell Biol 113:1145-57 (1991). 10. Airey JA et al. J Biol Chem 265:14187-94 (1990). 11. Olivares EB et al. Biophys J 59:1153-63 (1991).
Additional info: Recognizes chicken Ryanodine Receptor (RyR)-1 and RyR-2 isoforms. Species Crossreactivity: chicken alpha, beta and cardiac isoforms, mouse RyR-3, frog, alpha and beta isoforms, fish alpha isoform. Species Crossreactivity: human, rabbit, rat, mouse, bovine, canine, sheep, fish and amphibians.

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