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Rocaglamide (Rocaglamide A)

Cat no: R2997-90

Supplier: United States Biological
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An immunosuppressant and a potent inhibitor of NF-kB activation in T cells, with an almost complete inhibition at 200nM. Suppresses cytokine production (IFN-g, TNF-a, IL-2 and IL-4) and inhibits NF-AT in peripheral blood T cells at concentrations that do not impair NF-kB and AP-1 activities. Also induces mitochondria-mediated apoptosis in leukemia cells and sensitizes CD95/CD95L-mediated apoptosis in malignant T-cells by differential regulation of CD95L and c-FLIP expression. Molecular Weight: ~505.56 Solubility: DMSO or EtOH Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO or EtOH. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: R2997-90
Size: 100ug
Form: Supplied as a white to off-white solid.
Purity: ~98% (HPLC)
References: 1. Jhu, J.Y., et al. (2009). Cell Death Differ. 16, 1289-1299.

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