Home  >  Products  >  RNA Binding Motif Protein 8A (RNA-binding Motif Protein 8A, RBM8a, RNA Binding Protein 8A, Binder of OVCA1 1, Binder of OVCA1-1, BOV 1, BOV-1, BOV 1A, BOV-1A, BOV 1B, BOV-1B, BOV-1C, HSPC114, MDS014, Ribonucleoprotein RBM8, Ribonucleoprotein RBM8A, RNA Bi

RNA Binding Motif Protein 8A (RNA-binding Motif Protein 8A, RBM8a, RNA Binding Protein 8A, Binder of OVCA1 1, Binder of OVCA1-1, BOV 1, BOV-1, BOV 1A, BOV-1A, BOV 1B, BOV-1B, BOV-1C, HSPC114, MDS014, Ribonucleoprotein RBM8, Ribonucleoprotein RBM8A, RNA Bi

Cat no: R2033-08A


Supplier: United States Biological
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Pre-mRNA splicing appears to play an important role in regulation of gene expression. It has been shown in a number of studies that during the splicing process, specific proteins are recruited to the mRNA and assemble into a complex of mRNA-protein near the exon-exon junction. This complex is termed mRNA-protein complex (mRNP), or the exon-exon junction complex. Several proteins were found to be present in this complex including Y14, magoh, Aly/REF, RNPS1, Upf3, and DEK. Y14 is a 174 amino acid RNA-binding protein that contains one RNA-binding domain in the middle of the protein. Y14 binds to the spliced mRNAs in the nucleus and is exported with the mRNA to the cytoplasm. Similar to other proteins in the mRNA-protein complex, Y14 can interact with the mRNA export factor TAP and enhance the export of the mRNAs. Y14 binds to different mRNAs approx. Applications: Suitable for use in Immunofluorescence, ELISA, Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Cellular Localization: Cytoplasmic and Nuclear Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 3 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: R2033-08A
Reactivities: Human, Xenopus/Amphibian
Hosts: Mouse
Applications: ELISA, Immunofluorescence, Immunoprecipitation, Western Blot
Size: 50ul
Form: 0.01M PBS, pH 7.4 containing 15mM sodium azide
P type: Mab
Isotype: IgG2b
Purity: Purified by Protein A affinity chromatography.
References: 1. Kataoka, N., et al., Mol. Cell, 6, 673-682(2000). 2. Kim, V.N., et al., EMBO J., 20, 2062-2068(2001). 3. Kataoka, N., et al., J. Biol. Chem., 279, 7009-7013 (2004). 4. Kim, V.N., et al., Mol. Cells, 12, 1-10 (2001). 5. Kim, V.N., et al., Science, 293, 1832-1836 (2001).
Additional info: Species Crossreactivity: Crossreacts with Human and Xenopus laevis.

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